Agmatine & nerve healing

///Agmatine & nerve healing
Agmatine & nerve healing

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  • Avataranna
    Participant
    Post count: 12

    Hi Dr Corenman,
    After being diagnosed with lumbar radiculopathy due to disc herniation, I was prescribed Gabapentin, but greatly disliked it’s side effects. Then I came across some studies online that suggested agmatine might help relieve pain associated with sciatica. I tried taking agmatine for several weeks, but it did not noticeably alleviate my pain. In any event, my herniation seemed destined to cause me great agony because it only worsened despite 3 months of dedicated conservative care and I elected to have an Endoscopic Microdisectomy 3 weeks ago. My neurosurgeon appears to have successfully cut out my pain, but I am wondering if there is anything I can take to help my nerves heal/recover? I am still experiencing some minor pain when I first rise from a lying to standing position, but it feels less like my old sciatic pain, but more like nerve inflammation. I’m also experiencing numbness for the first time in the area. I’ve resumed taking agmatine in case it might help heal my nerves as they were quite compressed from my large, contained herniation. Of course, this minor discomfort is one I can live with and a tremendous improvement from the excruciating pain I was in pre-surgery. I just want to help my nerves out any way I can. I would appreciate any insight/wisdom you could share!

    AvatarDonald Corenman, MD, DC
    Moderator
    Post count: 7138

    Unfortunately, there are no medications other than steroids that will help the nerve root heal. Other than taking the compression off the nerve, metabolic faults can be corrected. If there are metabolic faults (uncontrolled diabetes, electrolyte imbalances), correction of these can help the nerve heal.

    Dr. Corenman

    PLEASE REMEMBER, THIS FORUM IS MEANT TO PROVIDE GENERAL INFORMATION ON SPINE ANATOMY, CONDITIONS AND TREATMENTS. TO GET AN ACCURATE DIAGNOSIS, YOU MUST VISIT A QUALIFIED PROFESSIONAL IN PERSON.
     
    Donald Corenman, MD, DC is a highly-regarded spine surgeon, considered an expert in the area of neck and back pain. Trained as both a Medical Doctor and Doctor of Chiropractic, Dr. Corenman earned academic appointments as Clinical Assistant Professor and Assistant Professor of Orthopaedic Surgery at the University of Colorado Health Sciences Center, and his research on spine surgery and rehabilitation has resulted in the publication of multiple peer-reviewed articles and two books.
    Avataranna
    Participant
    Post count: 12

    Thank you so much for your reply, Dr C. I did have an epidural steroidal injection 2 weeks before my surgery which greatly reduced my sciatic symptoms, but I still proceeded with my surgery (almost 4 weeks ago). So I’m hoping the steroid is still present and acting at reduced levels now at 6 weeks later.

    Do steroids heal nerves by reducing inflammation? If so, is it advisable to take NSAIDS short term to further attempt to reduce inflammation?

    Many, many thanks again.

    AvatarDonald Corenman, MD, DC
    Moderator
    Post count: 7138

    “Do steroids heal nerves by reducing inflammation”? Yes

    “Is it advisable to take NSAIDS short term to further attempt to reduce inflammation”. NSAIDs do reduce inflammation but only block one of the two pathways to inflammation so they are not as effective as corticosteroids. NSAIDs also can cause gastric upset so I don’t use them regularly.

    Dr. Corenman

    PLEASE REMEMBER, THIS FORUM IS MEANT TO PROVIDE GENERAL INFORMATION ON SPINE ANATOMY, CONDITIONS AND TREATMENTS. TO GET AN ACCURATE DIAGNOSIS, YOU MUST VISIT A QUALIFIED PROFESSIONAL IN PERSON.
     
    Donald Corenman, MD, DC is a highly-regarded spine surgeon, considered an expert in the area of neck and back pain. Trained as both a Medical Doctor and Doctor of Chiropractic, Dr. Corenman earned academic appointments as Clinical Assistant Professor and Assistant Professor of Orthopaedic Surgery at the University of Colorado Health Sciences Center, and his research on spine surgery and rehabilitation has resulted in the publication of multiple peer-reviewed articles and two books.
    Avataranna
    Participant
    Post count: 12

    Dr C,
    Why can’t more doctors be like you? Here you are answering our questions and providing this invaluable service for nothing in return… but our gratitude and admiration. I have been trying to get my surgeon and his nurse to call me back with an answer to this question for several days now with no success. Argh.

    I have one last question on this topic. I’m at the 4 week post disectomy mark….Is it better to request a Medrol dose pack now (get my nerves calmed down sooner than later) or is it better to wait a few more weeks/months (in case there are benefits to the body’s natural inflammation response)?

    With deepest gratitude,
    Anna

    AvatarDonald Corenman, MD, DC
    Moderator
    Post count: 7138

    Medrol dose packs or other oral steroids reduce inflammation, the real bane of a nerve root. Nonetheless, I look at these medications as “pain medications” and not as real healing. A counterargument however is that we do put patients immediately on high dose steroids for spinal cord injury so it is a two way street. There are some risks with steroid use so that is why they are not used liberally.

    Dr. Corenman

    PLEASE REMEMBER, THIS FORUM IS MEANT TO PROVIDE GENERAL INFORMATION ON SPINE ANATOMY, CONDITIONS AND TREATMENTS. TO GET AN ACCURATE DIAGNOSIS, YOU MUST VISIT A QUALIFIED PROFESSIONAL IN PERSON.
     
    Donald Corenman, MD, DC is a highly-regarded spine surgeon, considered an expert in the area of neck and back pain. Trained as both a Medical Doctor and Doctor of Chiropractic, Dr. Corenman earned academic appointments as Clinical Assistant Professor and Assistant Professor of Orthopaedic Surgery at the University of Colorado Health Sciences Center, and his research on spine surgery and rehabilitation has resulted in the publication of multiple peer-reviewed articles and two books.
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