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  • cdebrun2002
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    Post count: 11

    I am a 39 year old male. I have had 2 back fusions of L5/S1 and L4/L5. My last surgery was in May of 13 and about two weeks afterwards I was diagnosed with a pretty severe infection in my back. After 6 weeks of a pic line the infection was gone. Last week I had an MRI done, due to continuing pain, and it showed fairly severe Modic Type I changes in L4, and vertebral edema in L4. I have read a study that suggests my current pain, (which is in my back muscles, as opposed to the radiating nerve pain prior to surgery) could be caused by a low virulent bacterial infection in the vertebral body. My ESR is 15 and my WBC is 8.26 so my Dr. is not comfortable treating me for an infection. Is it possible to still have a vertebral infection, even if these blood tests are normal?

    Donald Corenman, MD, DC
    Moderator
    Post count: 8660

    It is possible but unlikely that you might have a continuing infection of Propionibacterium acnes. This is a typical skin bacteria (we all have bacterial that live on and in our skin) and has such low virulence (the ability to cause damage to tissues), that infection can go undetected occasionally because the symptoms are so mild.

    infection by P. Acnes is possible with a lower ESR and CRP (lab tests that indicate presence of infection) but this would be unusual. If your “first” infection was from another organism (strep or staph), it would be even more unusual that P. Acnes is still present.

    I would assume that you have a pseudoarthrosis (lack of fusion) of this level due to the MRI changes and not a smoldering infection. Do you have an X-ray with flexion/extension views or a CT that demonstrates solid fusion?

    Dr. Corenman

    .

    PLEASE REMEMBER, THIS FORUM IS MEANT TO PROVIDE GENERAL INFORMATION ON SPINE ANATOMY, CONDITIONS AND TREATMENTS. TO GET AN ACCURATE DIAGNOSIS, YOU MUST VISIT A QUALIFIED PROFESSIONAL IN PERSON.
     
    Donald Corenman, MD, DC is a highly-regarded spine surgeon, considered an expert in the area of neck and back pain. Trained as both a Medical Doctor and Doctor of Chiropractic, Dr. Corenman earned academic appointments as Clinical Assistant Professor and Assistant Professor of Orthopaedic Surgery at the University of Colorado Health Sciences Center, and his research on spine surgery and rehabilitation has resulted in the publication of multiple peer-reviewed articles and two books.
    cdebrun2002
    Member
    Post count: 11

    The Immunologist that treated my post-operative infection told me that my infection was the result of skin bacteria, but I can’t find the exact one in any of my test results. My WBC at the time was 18, my ESR was 107, and my CRP was 379. They admitted me to the hospital for three days during it, and while it wasn’t a staph or strep infection they were pretty worried. Would the strength of the original infection make a difference now?
    I did have a CT that showed I have pseudoarthrosis. I guess that I am just confused. The only cause I could really find online for the Modic I change and edema was infection. But that’s just another great reason to talk to an expert like you, instead of relying on my own googling skills. Would the pseudoarthrosis cause the Modic I change and edema in L4? Could you point me to a resource that could explain the mechanics of this pain generation? Until I can picture in my mind’s eye what’s going on down there, I’ll continue to go crazy. I think the worst part of all this, is being in pain and not understanding why.
    Thank you so much for taking the time to answer all our questions. The peace of mind you’re providing is priceless.

    Donald Corenman, MD, DC
    Moderator
    Post count: 8660

    Most likely your pain is from the pseudoarthrosis. When the vertebra fails to fuse, it starts to fracture against its neighbors. This fracturing is what causes the Modic changes which are just trabecular fractures and post fracture edema (swelling). The pain is from abnormal loads to the bone causing these fractures.

    Most likely, you have what I call delayed onset pain or PFILP (pay for it later pain). This occurs due to the inflammatory cascade which takes anywhere from 3-12 hours to occur. When you are at the peak of this cycle, the pain increases and it might be hard to sleep due to the throbbing nature of the pain.

    This is generally not dangerous pain but can be disabling.

    Dr. Corenman

    PLEASE REMEMBER, THIS FORUM IS MEANT TO PROVIDE GENERAL INFORMATION ON SPINE ANATOMY, CONDITIONS AND TREATMENTS. TO GET AN ACCURATE DIAGNOSIS, YOU MUST VISIT A QUALIFIED PROFESSIONAL IN PERSON.
     
    Donald Corenman, MD, DC is a highly-regarded spine surgeon, considered an expert in the area of neck and back pain. Trained as both a Medical Doctor and Doctor of Chiropractic, Dr. Corenman earned academic appointments as Clinical Assistant Professor and Assistant Professor of Orthopaedic Surgery at the University of Colorado Health Sciences Center, and his research on spine surgery and rehabilitation has resulted in the publication of multiple peer-reviewed articles and two books.
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