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Hi Dr. Corenman,
About 2 years ago I contacted you about severe back pain post L5-S1 fusion. After reviewing my images, you mentioned ” modic changes” and a herniated disk. Because of this information, I was able to research the importance of modic changes. I am a research nurse so I knew what to look for. There were a few small studies that showed a 4 month course of Amoxicillin-Clavulin cleared the infection that the modic changes represented.
I took this RX, prescribed by my GP (!) for 4 months ( Feb-May). I am now pretty much pain free. I do continue to do trigger point therapy, using small balls, every night to take care of the muscle spasms. But all the nerve and severe localized back pain is gone and my spine is no longer hot in that one area.
Thank you very much and I hope this info helps other patients and/or your research.
Leslie, Vancouver, CanadaThanks for keep us informed of your progress.
it is my opinion that these modic changes are actually endplate fractures due to stress overload of the degenerative disc. If these endplate changes were really bacterial infections, all of my patients who undergo surgery for this condition should have become infected but my infection rate is below 0.5%.
In addition, I took cultures for a while of these patients undergoing fusion and did not find any growth from the biopsied bone samples. Also, some of my fusion patients had undergone the six month antibiotic treatment without any relief and then had undergone fusion with full relief of symptoms.
Nonetheless, there seems to be some interesting data regarding a small percentage of patients who have undergone antibiotic treatment with symptom reduction as you have personally noted. I do not think this is an actual eradication of a P Acnes infection but there is something that these antibiotics can do for a small percentage of patients. What the mechanism is is currently unknown. The downside of this prolonged exposure to antibiotics is the potential for complications.
Dr. Corenman
PLEASE REMEMBER, THIS FORUM IS MEANT TO PROVIDE GENERAL INFORMATION ON SPINE ANATOMY, CONDITIONS AND TREATMENTS. TO GET AN ACCURATE DIAGNOSIS, YOU MUST VISIT A QUALIFIED PROFESSIONAL IN PERSON.
Donald Corenman, MD, DC is a highly-regarded spine surgeon, considered an expert in the area of neck and back pain. Trained as both a Medical Doctor and Doctor of Chiropractic, Dr. Corenman earned academic appointments as Clinical Assistant Professor and Assistant Professor of Orthopaedic Surgery at the University of Colorado Health Sciences Center, and his research on spine surgery and rehabilitation has resulted in the publication of multiple peer-reviewed articles and two books. -
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